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Penn State is currently testing a possible cure for breast cancer. In the only known cure that has tested to be effective in 100%, PSU may have found the silver bullet in the fight against breast cancer.
Thursday, September 22, 2011
HERSHEY, Pa. -- A nondisease-causing virus kills human breast cancer cells in the laboratory, creating opportunities for potential new cancer therapies, according to Penn State College of Medicine researchers who tested the virus on three different breast cancer types that represent the multiple stages of breast cancer development.
Adeno-associated virus type 2 (AAV2) is a virus that regularly infects humans but causes no disease. Past studies by the same researchers show that it promotes tumor cell death in cervical cancer cells infected with human papillomavirus. Researchers used an unaltered, naturally occurring version of AAV2 on human breast cancer cells.
"Breast cancer is the most prevalent cancer in the world and is the leading cause of cancer-related death in women," said Samina Alam, research associate in microbiology and immunology. "It is also complex to treat."
Craig Meyers, professor of microbiology and immunology, said breast cancer is problematic to treat because of its multiple stages. "Because it has multiple stages, you can't treat all the women the same. Currently, treatment of breast cancer is dependent on multiple factors such as hormone-dependency, invasiveness and metastases, drug resistance and potential toxicities. Our study shows that AAV2, as a single entity, targets all different grades of breast cancer."
Cells have multiple ways of dying. If damage occurs in a healthy cell, the cell turns on production and activation of specific proteins that allow the cell to commit suicide. However, in cancer cells these death pathways often are turned off, while the proteins that allow the cell to divide and multiply are stuck in the "on" position.
One way to fight cancer is to find ways to turn on these death pathways, which is what researchers believe is happening with the AAV2 virus.
In tissue culture dishes in the laboratory, 100 percent of the cancer cells are destroyed by the virus within seven days, with the majority of the cell death proteins activated on the fifth day. In another study, a fourth breast cancer derived cell line, which is the most aggressive, required three weeks to undergo cell death.
"We can see the virus is killing the cancer cells, but how is it doing it?" Alam said. "If we can determine which viral genes are being used, we may be able to introduce those genes into a therapeutic. If we can determine which pathways the virus is triggering, we can then screen new drugs that target those pathways. Or we may simply be able to use the virus itself."
Research needs to be completed to learn how AAV2 is killing cancer cells and which of its proteins are activating the death pathways. According to Meyers, the cellular myc gene seems to be involved. While usually associated with cell proliferation, myc is a protein also known to promote cell death. The scientists have observed increased expression of myc close to the time of death of the breast cancer cells in the study. They report their results in a recent issue of Molecular Cancer.
AAV2 does not affect healthy cells. However, if AAV2 were used in humans, the potential exists that the body's immune system would fight to remove it from the body. Therefore, by learning how AAV2 targets the death pathways, researchers potentially can find ways to treat the cancer without using the actual virus.
In ongoing studies, the Penn State researchers also have shown AAV2 can kill cells derived from prostate cancer, mesothelioma, squamous cell carcinoma, and melanoma. A fourth line of breast cancer cells -- representing the most aggressive form of the disease -- also was studied in a mouse breast tumor model, followed by treatment with AAV2. Preliminary results show the destruction of the tumors in the mice, and researchers will report the findings of those mouse studies soon.
Other researchers on this project are Brian S. Bowser and Mohd Israr, Department of Microbiology and Immunology; Michael J. Conway, Section of Infection Diseases, Yale School of Medicine; and Apurva Tandon, Department of Microbiology, Immunology and Pathology, Colorado State University.
The Pennsylvania Department of Health, Breast and Cervical Cancer Initiative supported this research. The researchers have filed for a U.S. patent on this work.
The University's Official News Source
GTFO with these posts and stop cluttering up TBB.
It will be one post a day, and I will not post everyday. But thanks.
Haters gon hate
Yeah...because there's so many more worthwhile things on tBB.
Great to hear this! We must save the breasts.
Great post and I hope you keep this up. That research sounds awesome.
im sure jive will post eventually, but we also have found a treatment that is onto animal testing for leukemia.... 100% effective (as of last year things might have changed since then)
“If you remember me, then I don't care if everyone else forgets.” ― Haruki Murakami
All of this is a save face... it makes you look incredibly desperate
How. This makes them look united and strong. PSU is a world class university. Dont hate because you think its what the masses think.
Maybe it is desperate. I probably wouldn't do what jive is doing, though I think it's interesting.
However, what's wrong with showing people the good things PSU has done? There are many reasons PSU fans can be proud of their school.
It's simple-minded to pretend that the one issue defines PSU.
Thanks for doing this Jive. We at PSU have the opportunity to save countless lives with the research that is going on and I think its important that people know that. Its such a shame that posts like this will distract tBB posters from all the incredibly important topics that riddle this cesspool.
This post was edited by CZ148 19 months ago
gingers don't understand "unity"
couldnt post 36 major achievments for auburn outside of sports... yet alone 300
Auburn has also never covered up child molestation for over a decade either. You are also kidding yourself if you think these threads will rehab Ped State's image. I dont see that happening at all
This post was edited by aubie25 19 months ago
It does sound desperate. No other poster is pumping their school like this. The only reason he is, is to sugar-coat the child rape and coverup. Would he be posting this if sandusky was still sodomizing children and joepa was still looking the other way?
Have they developed a virus that kills kid diddlers yet?
pretty sure any virus that kills a normal person would kill a pedophile... so to answer your sarcastic question... yes?
I wish we could get past all the PSU bashing, its enough already. What happened there was horrible. But the University itself is a great place, with great people who had nothing to do with what happened. Lets move on & give the University its alums & student body the chance to make good & heal their community.
Well, expect 363 more threads of PSU bashing. No amount of charity overlooks the horrors that took place. Sugarcoat it all you want, what happened is disgusting and should never be forgotten.
So I guess it counts for nothing that the person responsible will rot & die in prison, & that the people involved in covering it up are going to be punished as well? How about the crippling sanctions & 60 million? Not enough? What about the University enduring the most humiliating media witch hunt ever? Not yet? What else do you want or need to make it right? & You are right what happened should not be forgotten, but there comes a time, where it is time to move on & let the healing begin. You know due process & all.
Good idea why don't we invite the victims to give us the time line? When they are all better and have recovered from their ordeal we will call off the remebering of who allowed it and why.
OPPS my bad i forgot they never will, sorry but nice try.
In due time. Stay the course.
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